abstract：BACKGROUND & AIMS:Niemann-Pick C2 (NPC2) is a lysosomal protein involved in the egress of low-density lipoprotein-derived cholesterol from lysosomes to other intracellular compartments. NPC2 has been detected in several tissues and is also secreted from the liver into bile. We have previously shown that NPC2-deficient ...

journal_title：Journal of hepatology

authors： Acuña M,González-Hódar L,Amigo L,Castro J,Morales MG,Cancino GI,Groen AK,Young J,Miquel JF,Zanlungo S

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND & AIM:Hydrogen peroxide-inducible clone-5 (Hic-5), also named as transforming growth factor beta-1-induced transcript 1 protein (Tgfb1i1), was found to be induced by TGF-β. Previous studies have shown that TGF-β is a principal mediator of hepatic stellate cell (HSC) activation in liver fibrosis. However, thi...

journal_title：Journal of hepatology

authors： Lei XF,Fu W,Kim-Kaneyama JR,Omoto T,Miyazaki T,Li B,Miyazaki A

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND & AIMS:The MELD score predicts short-term mortality in patients with cirrhosis; however, some patients with low scores develop complications and die unexpectedly. Consequently, we evaluated the diagnostic accuracy of the methacetin breath test (MBT), an assay of liver metabolic function, and the MELD score, ...

journal_title：Journal of hepatology

authors： Stravitz RT,Reuben A,Mizrahi M,Lalazar G,Brown K,Gordon SC,Ilan Y,Sanyal A

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND & AIMS:Serological markers of hepatocellular carcinoma (HCC) indicate its invasiveness. We aimed to investigate whether the prognostic impact of surgical resection (SR) and radiofrequency thermal ablation (RFA) on patients with single nodular HCC ⩽5cm were different regarding positive conditions of the follo...

journal_title：Journal of hepatology

authors： Ueno M,Hayami S,Shigekawa Y,Kawai M,Hirono S,Okada K,Tamai H,Shingaki N,Mori Y,Ichinose M,Yamaue H

更新日期：2015-12-01 00:00:00

abstract：:The peripheral arterial vasodilation hypothesis has been most influential in the field of cirrhosis and its complications. It has given rise to hundreds of pathophysiological studies in experimental and human cirrhosis and is the theoretical basis of life-saving treatments. It is undisputed that splanchnic arterial va...

journal_title：Journal of hepatology

authors： Bernardi M,Moreau R,Angeli P,Schnabl B,Arroyo V

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND & AIMS:ER stress promotes liver fat accumulation and induction of inflammatory cytokines, which contribute to the development of steatohepatitis. Unresolved ER stress upregulates the pro-apoptotic CHOP. IL-1α is localized to the nucleus in apoptotic cells, but is released when these cells become necrotic and...

journal_title：Journal of hepatology

authors： Kandel-Kfir M,Almog T,Shaish A,Shlomai G,Anafi L,Avivi C,Barshack I,Grosskopf I,Harats D,Kamari Y

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND & AIMS:Urgency-based allocation that relies on the MELD score prioritizes patients at the highest risk of waitlist mortality. However, identifying patients at greatest risk for short-term post-transplant mortality is needed in order to optimize the potential gains in overall survival obtained through improve...

journal_title：Journal of hepatology

authors： Bittermann T,Makar G,Goldberg DS

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatic stellate cell activation is a wound-healing response to liver injury. However, continued activation of stellate cells during chronic liver damage causes excessive matrix deposition and the formation of pathological scar tissue leading to fibrosis and ultimately cirrhosis. The importance of sus...

journal_title：Journal of hepatology

authors： Mannaerts I,Leite SB,Verhulst S,Claerhout S,Eysackers N,Thoen LF,Hoorens A,Reynaert H,Halder G,van Grunsven LA

更新日期：2015-09-01 00:00:00

abstract：:The liver has come a long way since it was considered only a metabolic organ attached to the gastrointestinal tract. The simultaneous ascension of immunology and intravital microscopy evidenced the liver as a central axis in the immune system, controlling immune responses to local and systemic agents as well as diseas...

journal_title：Journal of hepatology

authors： Marques PE,Oliveira AG,Chang L,Paula-Neto HA,Menezes GB

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND & AIMS:The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is affected by epigenetic factors as well as by genetic variation. METHODS:We performed targeted-bisulfite sequencing to determine the levels of DNA methylation of 4 CpG islands (CpG99, CpG71, CpG26, and CpG101) in the regulatory regions o...

journal_title：Journal of hepatology

authors： Kitamoto T,Kitamoto A,Ogawa Y,Honda Y,Imajo K,Saito S,Yoneda M,Nakamura T,Nakajima A,Hotta K

更新日期：2015-08-01 00:00:00

abstract：:The high incidence of non-anastomotic biliary strictures (NAS) after transplantation of livers from extended criteria donors is currently a major barrier to widespread use of these organs. This review provides an update on the most recent advances in the understanding of the etiology of NAS. These new insights give re...

journal_title：Journal of hepatology

authors： Weeder PD,van Rijn R,Porte RJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND & AIMS:The incidence of metabolic syndrome-related hepatocellular carcinoma (MS-HCC) is increasing worldwide. High resection risks are anticipated because of underlying steatohepatitis, but long-term results are unknown. To clarify the outcomes following liver resection in patients with MS-HCC and to compare...

journal_title：Journal of hepatology

authors： Viganò L,Conci S,Cescon M,Fava C,Capelli P,D'Errico A,Torzilli G,Di Tommaso L,Giuliante F,Vecchio FM,Salizzoni M,David E,Pinna AD,Guglielmi A,Capussotti L

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND & AIMS:Prevalence data for hepatitis B and C and an evaluation of a guideline based screening in the primary care setting are not yet available. We therefore implemented a hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) screening and developed guideline based screening strategies. METHO...

journal_title：Journal of hepatology

authors： Wolffram I,Petroff D,Bätz O,Jedrysiak K,Kramer J,Tenckhoff H,Berg T,Wiegand J,German Check-Up 35+ Study Group.

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND & AIMS:Alcohol is the main contributing factor of alcoholic cirrhosis, but less is known about the significance of drinking pattern. METHODS:We investigated the risk of alcoholic cirrhosis among 55,917 participants (aged 50-64 years) in the Danish Cancer, Diet, and Health study (1993-2011). Baseline informa...

journal_title：Journal of hepatology

authors： Askgaard G,Grønbæk M,Kjær MS,Tjønneland A,Tolstrup JS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Simeprevir is an oral hepatitis C virus (HCV) NS3/4A protease inhibitor approved for treatment of chronic HCV infection. Baseline NS3 polymorphisms in all patients and emerging mutations in patients who failed to achieve sustained virologic response (SVR) with simeprevir plus peginterferon/ribavirin (...

journal_title：Journal of hepatology

authors： Lenz O,Verbinnen T,Fevery B,Tambuyzer L,Vijgen L,Peeters M,Buelens A,Ceulemans H,Beumont M,Picchio G,De Meyer S

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND & AIMS:Roles of alcohol consumption in non-alcoholic fatty liver disease are still controversial, although several cross-sectional studies have suggested the beneficial effect of light to moderate drinking on fatty liver. We analyzed the longitudinal relationship between drinking pattern and fatty liver. ME...

journal_title：Journal of hepatology

authors： Moriya A,Iwasaki Y,Ohguchi S,Kayashima E,Mitsumune T,Taniguchi H,Ando M,Yamamoto K

更新日期：2015-04-01 00:00:00

abstract：:Over the last three decades acute liver failure (ALF) has been transformed from a rare and poorly understood condition with a near universally fatal outcome, to one with a well characterized phenotype and disease course. Complex critical care protocols are now applied and emergency liver transplantation (ELT) is an es...

journal_title：Journal of hepatology

authors： Bernal W,Lee WM,Wendon J,Larsen FS,Williams R

更新日期：2015-04-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries that is predicted to become also the most frequent indication for liver transplantation by 2030. Over the last decade, it has been shown that the clinical burden of NAFLD is not only confined to liver-relat...

journal_title：Journal of hepatology

authors： Byrne CD,Targher G

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocyte-like cells (HLCs), differentiated from pluripotent stem cells by the use of soluble factors, can model human liver function and toxicity. However, at present HLC maturity and whether any deficit represents a true fetal state or aberrant differentiation is unclear and compounded by compariso...

journal_title：Journal of hepatology

authors： Baxter M,Withey S,Harrison S,Segeritz CP,Zhang F,Atkinson-Dell R,Rowe C,Gerrard DT,Sison-Young R,Jenkins R,Henry J,Berry AA,Mohamet L,Best M,Fenwick SW,Malik H,Kitteringham NR,Goldring CE,Piper Hanley K,Vallier L,

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:Genetic variants of patatin-like phospholipase domain-containing 3 (PNPLA3) and diabetes are associated with liver disease severity, in patients with chronic hepatitis C (CHC) infection. We aimed at exploring their interaction in determining hepatitis C virus (HCV)-related liver fibrosis. METHODS:The...

journal_title：Journal of hepatology

authors： Huang CF,Dai CY,Yeh ML,Huang CI,Tai CM,Hsieh MH,Liang PC,Lin YH,Hsieh MY,Yang HL,Huang JF,Lin ZY,Chen SC,Yu ML,Chuang WL

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:Ischemia-reperfusion (IR) of liver results in hepatocytes (HP) and sinusoidal endothelial cells (LSEC) irreversible damage. Ischemic preconditioning protects IR damage upon adenosine A2a receptor (A2aR) stimulation. Understanding the phenotypic changes that underlie hepatocellular damage and protectio...

journal_title：Journal of hepatology

authors： Mandili G,Alchera E,Merlin S,Imarisio C,Chandrashekar BR,Riganti C,Bianchi A,Novelli F,Follenzi A,Carini R

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND & AIMS:The insignificance of pure microsteatosis (MiS) was reported in living donor liver transplantation (LDLT). However, since steatosis is mostly found in a mixed form of microsteatosis (MiS) and macrosteatosis (MaS), we aimed to determine the importance of MiS mixed with MaS in LDLT. METHODS:Donor match...

journal_title：Journal of hepatology

authors： Han S,Ha SY,Park CK,Joh JW,Kwon CH,Kwon GY,Kim G,Gwak MS,Jeong WK,Ko JS

更新日期：2015-03-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Journal of hepatology

authors： Arai T,Kato Y,Ishimoto K,Kanai M,Shinjo S,Sayama K,Suzuki T,Doi T,Johnson RS,Suematsu M,Goda N

更新日期：2015-02-10 00:00:00

abstract：BACKGROUND & AIMS:During chronic HCV infection, T cell dependent virus-specific antibodies are produced. However, the role of B-T cell interaction in chronic HCV is largely unknown. CD4(+)CXCR5(+) T follicular helper (TFH)-cells activate B cells and are important for clearance of various chronic viral infections. We in...

journal_title：Journal of hepatology

authors： Spaan M,Kreefft K,de Graav GN,Brouwer WP,de Knegt RJ,ten Kate FJ,Baan CC,Vanwolleghem T,Janssen HL,Boonstra A

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND & AIMS:Because abdominal ultrasonography cannot reliably quantify hepatic steatosis, accurate data on the incidence of non-alcoholic fatty liver disease (NAFLD) are lacking. We aimed to study the population incidence of NAFLD with state-of-the-art non-invasive tests. METHODS:This was a prospective cohort st...

journal_title：Journal of hepatology

authors： Wong VW,Wong GL,Yeung DK,Lau TK,Chan CK,Chim AM,Abrigo JM,Chan RS,Woo J,Tse YK,Chu WC,Chan HL

更新日期：2015-01-01 00:00:00

abstract：:Clinical complexity, anatomic diversity and molecular heterogeneity of cholangiocarcinoma (CCA) represent a major challenge in the assessment of effective targeted therapies. Molecular and cellular mechanisms underlying the diversity of CCA growth patterns remain a key issue of clinical concern. Crucial questions comp...

journal_title：Journal of hepatology

authors： Raggi C,Invernizzi P,Andersen JB

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND & AIMS:SIRT1 is a class III histone deacetylase that plays diverse roles in various cancers. However, the clinical significance of SIRT1 in hepatocellular carcinoma (HCC) remains unknown. METHODS:We analysed p53 mutations and the activation of SIRT1 in 252 hepatitis B virus-positive HCC cases. None of the p...

journal_title：Journal of hepatology

authors： Zhang ZY,Hong D,Nam SH,Kim JM,Paik YH,Joh JW,Kwon CH,Park JB,Choi GS,Jang KY,Park CK,Kim SJ

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND & AIMS:Hallmarks of non-alcoholic fatty liver disease (NAFLD) are increased triglyceride accumulation within hepatocytes. The prevalence of NAFLD increases steadily with increasing thyrotropin (TSH) levels. However, the underlying mechanisms are largely unknown. Here, we focused on exploring the effect and m...

journal_title：Journal of hepatology

authors： Yan F,Wang Q,Lu M,Chen W,Song Y,Jing F,Guan Y,Wang L,Lin Y,Bo T,Zhang J,Wang T,Xin W,Yu C,Guan Q,Zhou X,Gao L,Xu C,Zhao J

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND & AIMS:Hepatocyte-like cells, differentiated from different stem cell sources, are considered to have a range of possible therapeutic applications, including drug discovery, metabolic disease modelling, and cell transplantation. However, little is known about how stem cells differentiate into mature and func...

journal_title：Journal of hepatology

authors： Chen KT,Pernelle K,Tsai YH,Wu YH,Hsieh JY,Liao KH,Guguen-Guillouzo C,Wang HW

更新日期：2014-12-01 00:00:00

abstract：:The term cirrhosis-associated immune dysfunction refers to the main syndromic abnormalities of immune function, immunodeficiency and systemic inflammation that are present in cirrhosis. The course of advanced cirrhosis, regardless of its aetiology, is complicated by cirrhosis-associated immune dysfunction and this con...

journal_title：Journal of hepatology

authors： Albillos A,Lario M,Álvarez-Mon M

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND & AIMS:Although the growth suppressing Hippo pathway has been implicated in hepatocellular carcinoma (HCC) pathogenesis, it is unknown at which stage of hepatocarcinogenesis its dysregulation occurs. We investigated in rat and human preneoplastic lesions whether overexpression of the transcriptional co-activ...

journal_title：Journal of hepatology

authors： Perra A,Kowalik MA,Ghiso E,Ledda-Columbano GM,Di Tommaso L,Angioni MM,Raschioni C,Testore E,Roncalli M,Giordano S,Columbano A

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND & AIMS:Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease usually requiring life-long immunosuppression. The mechanisms for disease initiation and chronicity are largely unknown. A contribution of deficient regulatory T cells (Tregs) in the blood was controversially discussed recently. So far i...

journal_title：Journal of hepatology

authors： Taubert R,Hardtke-Wolenski M,Noyan F,Wilms A,Baumann AK,Schlue J,Olek S,Falk CS,Manns MP,Jaeckel E

更新日期：2014-11-01 00:00:00

abstract：:Interferon-based treatments have a poor safety profile and limited efficacy in patients with advanced liver disease and in patients with hepatitis C (HCV) recurrence after liver transplantation (LT). Despite the recent approval of the first interferon-free regimen, which will be followed by several other interferon-fr...

journal_title：Journal of hepatology

authors： Gambato M,Lens S,Navasa M,Forns X

更新日期：2014-11-01 00:00:00

abstract：:The establishment of robust HCV cell culture systems and characterization of the viral life cycle provided the molecular basis for highly innovative, successful years in HCV drug development. With the identification of direct-acting antiviral agents (DAAs), such as NS3/4A protease inhibitors, NS5A replication complex ...

journal_title：Journal of hepatology

authors： Welzel TM,Dultz G,Zeuzem S

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND & AIMS:Lysosomal acid lipase deficiency is an autosomal recessive enzyme deficiency resulting in lysosomal accumulation of cholesteryl esters and triglycerides. LAL-CL04, an ongoing extension study, investigates the long-term effects of sebelipase alfa, a recombinant human lysosomal acid lipase. METHODS:Seb...

journal_title：Journal of hepatology

authors： Valayannopoulos V,Malinova V,Honzík T,Balwani M,Breen C,Deegan PB,Enns GM,Jones SA,Kane JP,Stock EO,Tripuraneni R,Eckert S,Schneider E,Hamilton G,Middleton MS,Sirlin C,Kessler B,Bourdon C,Boyadjiev SA,Sharma R,Twe

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND & AIMS:There is little information regarding the extent to which difficult to cure patients with advanced liver fibrosis, due to hepatitis C virus genotype-1 (HCV-1) can successfully and safely be treated with triple therapy with telaprevir (TVR), pegylated interferon alpha (P) and ribavirin (R). In the TVR ...

journal_title：Journal of hepatology

authors： Colombo M,Strasser S,Moreno C,Abrao Ferreira P,Urbanek P,Fernández I,Abdurakmonov D,Streinu-Cercel A,Verheyen A,Iraqi W,DeMasi R,Hill A,Lonjon-Domanec I,Wedemeyer H

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND & AIMS:HCV requires host lipid metabolism for replication, and apolipoproteins have been implicated in the response to treatment. METHODS:We examined plasma apolipoprotein concentrations in three cohorts of patients: mono-infected patients with symptomatic acute hepatitis C (aHCV); those undergoing treatmen...

journal_title：Journal of hepatology

authors： Laird ME,Mohsen A,Duffy D,Mamdouh R,LeFouler L,Casrouge A,El-Daly M,Rafik M,Abdel-Hamid M,Soulier A,Pawlotsky JM,Hézode C,Rosa I,Renard P,Mohamed MK,Bonnard P,Izopet J,Mallet V,Pol S,Albert ML,Fontanet A

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND & AIMS:CD4(+) CD25(+) Foxp3(+) regulatory T cells (Tregs) have a profound ability to control immune responses. We have previously shown that the liver is a major source of peripherally induced Tregs. Here, we investigate the liver cell types and molecular mechanisms responsible for hepatic Treg induction. M...

journal_title：Journal of hepatology

authors： Carambia A,Freund B,Schwinge D,Heine M,Laschtowitz A,Huber S,Wraith DC,Korn T,Schramm C,Lohse AW,Heeren J,Herkel J

更新日期：2014-09-01 00:00:00

abstract：:The EASL Monothematic Conference on Translational Research in Viral Hepatitis brought together a group of leading scientists and clinicians working on both, basic and clinical aspects of viral hepatitis, thereby building bridges from bench to bedside. This report recapitulates the presentations and discussions at the ...

journal_title：Journal of hepatology

authors： Boettler T,Moradpour D,Thimme R,Zoulim F

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND & AIMS:The accuracy of creatinine-based estimated GFR (eGFR) in assessing the prevalence of chronic kidney disease (CKD) and associated mortality after liver transplantation (LTx) is unknown. Using measured GFR (mGFR) by iothalamate clearance, we determined the prevalence of the entire spectrum of renal dysf...

journal_title：Journal of hepatology

authors： Allen AM,Kim WR,Therneau TM,Larson JJ,Heimbach JK,Rule AD

更新日期：2014-08-01 00:00:00